A report by the Government Accountability Office states, "The involvement of Xanax – a sedative used to treat anxiety, insomnia, and seizures – is particularly troubling as previous studies have shown that people who were prescribed both methadone and Xanax were at greater risk of overdose than those prescribed only one of these drugs."
According to cdc.gov the risks of methadone include:
- The difference between prescribed doses and dangerous doses of methadone is small.
- Methadone has special risks as a painkiller. For example, taking it more than 3 times a day can cause the drug to build up in a person’s body, leading to dangerously slowed breathing.
- Methadone can seriously disrupt the heart’s rhythm.
- Methadone can be particularly risky when used with tranquilizers or other prescription painkillers.
- In one study, four in ten overdose deaths involving single prescription painkillers involved methadone, twice as many as any other prescription painkiller.





